abstract：BACKGROUND:Accumulating evidence suggests that Foxp3+ regulatory T (Treg) cells act as inhibitory mediators of inflammation; however, the in vivo mechanism underlying this protection remains elusive in liver diseases. AIMS:To clarify the in vivo role of Foxp3+ Treg cells in liver fibrosis, we used the DEREG mouse, whi...

journal_title：Digestive diseases and sciences

authors： Roh YS,Park S,Lim CW,Kim B

更新日期：2015-07-01 00:00:00

abstract：AIM:To perform a systematic review and meta-analysis of the effectiveness and complications of BRTO for gastric varices. MATERIALS AND METHODS:A systematic review was performed to identify relevant articles. Inclusion criteria were applied to select studies with at least ten patients with acute bleeding or at-risk gas...

journal_title：Digestive diseases and sciences

authors： Park JK,Saab S,Kee ST,Busuttil RW,Kim HJ,Durazo F,Cho SK,Lee EW

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Different factors have been associated with prolonged fluoroscopy time (FT) during endoscopic retrograde cholangiopancreatography (ERCP). AIM:We hypothesize that FT depends on both the anatomical location of the pathology managed during ERCP and the complexity of the ERCP. METHODS:Three centers participate...

journal_title：Digestive diseases and sciences

authors： Alkhatib AA,Abdel Jalil AA,Faigel DO,Pannala R,Crowell M,Harrison ME

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND AND AIM:Population-based endoscopic studies of esophageal eosinophilia and eosinophilic esophagitis are limited in the world. This study was aiming to describe features of esophageal eosinophilia and eosinophilic esophagitis in a representative sample of the adult in Shanghai, China. METHODS:As part of a la...

journal_title：Digestive diseases and sciences

authors： Ma X,Xu Q,Zheng Y,Zhao Y,Lu J,Wang R,Li Z,Zou D,He J

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND AND AIM:Dietary fiber shortens gut transit time, but data on the effects of fiber components (including resistant starch, RS) on intestinal contractility are limited. We have examined RS effects in male Sprague-Dawley rats fed either a high-amylose maize starch (HAMS) or a wholemeal made from high-amylose wh...

journal_title：Digestive diseases and sciences

authors： Patten GS,Kerr CA,Dunne RA,Shaw JM,Bird AR,Regina A,Morell MK,Lockett TJ,Molloy PL,Abeywardena MY,Topping DL,Conlon MA

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Prior to the consensus guideline conference in 2007, eosinophilic esophagitis (EoE) was uncommon dominated by the fibrostenotic phenotype, but over the past decade has become a common cause of dysphagia with more inflammatory phenotypes diagnosed. We assessed the impact of guideline definitions on t...

journal_title：Digestive diseases and sciences

authors： Lipka S,Boyce HW,Kumar A,Richter JE

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Endoscopic treatment is effective in the treatment of patients with bile duct injury after cholecystectomy. We aimed to investigate the long-term results of endoscopic treatment, factors predicting the recurrence of the stricture, and to determine the optimal endoscopic treatment. METHODS:The study...

journal_title：Digestive diseases and sciences

authors： Parlak E,Dişibeyaz S,Ödemiş B,Köksal AŞ,Küçükay F,Şaşmaz N,Şahin B

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Accumulating evidence has indicated that variations of mitochondrial DNA (mtDNA) content may affect the susceptibility to hepatocellular carcinoma (HCC). However, no study has been conducted to evaluate the association of circulating mtDNA content and the risk of liver cirrhosis, a leading cause of ...

journal_title：Digestive diseases and sciences

authors： Wang C,Hann HW,Hann RS,Wan S,Myers RE,Ye Z,Xing J,Yang H

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND AND AIM:The liver has a high capacity of its regeneration. Most hepatic cells are quiescent unless otherwise stimulated such as their injury or ablation. A previous study suggest that pre-activated hepatic cells have a positive effect on their regeneration. In this study, we examined whether the pre-activate...

journal_title：Digestive diseases and sciences

authors： Arioka Y,Ito H,Ando T,Ogiso H,Hirata A,Hara A,Seishima M

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:The principle of treating-to-target has been successfully applied to many diseases with significant improvement in patient care and as a useful guidance for healthcare providers. Appreciation of the central role for arterial vasodilatation in the pathogenesis of hepatorenal syndrome (HRS) has led to routine ...

journal_title：Digestive diseases and sciences

authors： Cai CX,Maddukuri G,Jaipaul N,Zhang Z

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Gut inflammation is prevalent in chronic kidney disease (CKD) and likely contributes to systemic inflammation via disruption of the epithelial tight junction with subsequent endotoxin and bacterial translocation. AIMS:To study the expression profile of inflammatory and tight junction proteins in the colon f...

journal_title：Digestive diseases and sciences

authors： Lau WL,Liu SM,Pahlevan S,Yuan J,Khazaeli M,Ni Z,Chan JY,Vaziri ND

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Liver stiffness measurement (LSM) by transient elastography is a popular noninvasive test of fibrosis. Traditional LSM cutoffs dichotomize patients and do not clearly indicate the confidence of diagnosis. AIM:We derived and validated probability functions of fibrosis and cirrhosis based on LSM and determine...

journal_title：Digestive diseases and sciences

authors： Wong VW,Lampertico P,de Lédinghen V,Chang PE,Kim SU,Chen Y,Chan HL,Mangia G,Foucher J,Chow WC,Ahn SH,Hou J

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Given the rising epidemics of obesity and metabolic syndrome, nonalcoholic steatohepatitis (NASH) is now the most common cause of liver disease in the developed world. Effective treatment for NASH, either to reverse or prevent the progression of hepatic fibrosis, is currently lacking. AIM:To define the pred...

journal_title：Digestive diseases and sciences

authors： Glass LM,Dickson RC,Anderson JC,Suriawinata AA,Putra J,Berk BS,Toor A

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Obesity is considered a risk factor for other chronic diseases, and diets rich in lipids can cause alterations in the intestinal functions. AIM:The aim of this study was to investigate the effects of a high-fat diet (HFD) on the myenteric plexus of the large intestine in mice. METHODS:Swiss mice were distr...

journal_title：Digestive diseases and sciences

authors： Beraldi EJ,Soares A,Borges SC,de Souza AC,Natali MR,Bazotte RB,Buttow NC

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Corticotropin-releasing factor (CRF) peptides exert profound effects on the secretomotor function of the gastrointestinal tract. Nevertheless, despite the presence of CRF peptides and receptors in colonic tissue, their influence on colonic blood flow (CBF) is unknown. AIM:To determine the effect and mechani...

journal_title：Digestive diseases and sciences

authors： Akiba Y,Kaunitz JD,Million M

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND AND AIMS:The impact of obesity on survival following liver transplantation is unclear, and existing studies report conflicting results. Our current study aims to further delineate the impact of obesity using population-based registry data from the USA. METHODS:All US adult liver transplant recipients from 2...

journal_title：Digestive diseases and sciences

authors： Wong RJ,Cheung R,Perumpail RB,Holt EW,Ahmed A

更新日期：2015-04-01 00:00:00

abstract：:Colonoscopy is the dominant colorectal cancer screening strategy in the USA. There are no randomized controlled trials completed of screening colonoscopy, but multiple lines of evidence establish that colonoscopy reduces colorectal cancer incidence in both the proximal and distal colon. Colonoscopy is highly operator ...

journal_title：Digestive diseases and sciences

authors： Rex DK

更新日期：2015-03-01 00:00:00

abstract：UNLABELLED:There is a wide choice of fecal occult blood tests (FOBTs) for colorectal cancer screening. GOAL:To highlight the issues applicable when choosing a FOBT, in particular which FOBT is best suited to the range of screening scenarios. Four scenarios characterize the constraints and expectations of screening pro...

journal_title：Digestive diseases and sciences

authors： Young GP,Symonds EL,Allison JE,Cole SR,Fraser CG,Halloran SP,Kuipers EJ,Seaman HE

更新日期：2015-03-01 00:00:00

abstract：:This review article deals with the clinical value of capsule endoscopy for visualization of the colon. Since its introduction in 2006, the colon capsule endoscopy underwent major technological improvements. The improved performance of colon capsule endoscopy is reviewed based on three multicenter prospective studies. ...

journal_title：Digestive diseases and sciences

authors： Eliakim R,Adler SN

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND AND AIM:Self-expandable metal stents (SEMSs) have been a good treatment option for malignant intestinal obstruction. However, stent placement with a gastroscope can be technically difficult for the distal duodenum obstruction. A side-viewing duodenoscope may be helpful for these patients. We report our exper...

journal_title：Digestive diseases and sciences

authors： Park JM,Min BH,Lee SH,Chung KH,Lee JM,Song BJ,Lee JK,Ryu JK,Kim YT

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:The prevalence of advanced liver disease and its complications may be on the rise within the Medicare population. The study aim was trend assessment for prevalence, mortality and resource utilization of patients with advanced liver disease. METHODS:A retrospective, cross-sectional design was used to analyze...

journal_title：Digestive diseases and sciences

authors： Otgonsuren M,Henry L,Hunt S,Venkatesan C,Mishra A,Younossi ZM

更新日期：2015-02-01 00:00:00

abstract：:A variety of human disease conditions are associated with chronic intestinal disorders or enteropathies that are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Such disruptions in the homeostasis of the gastrointestinal (GI) tract can lead to symptoms of...

journal_title：Digestive diseases and sciences

authors： Petschow BW,Burnett BP,Shaw AL,Weaver EM,Klein GL

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Restoring normal fecal flora through intestinal microbiota transplantation (IMT) was successful in curing recurrent Clostridium difficile infection (CDI). However, only a few cases have been reported of IMT being utilized for the treatment of severe or fulminant CDI. AIM:Is IMT a simple and effective treatm...

journal_title：Digestive diseases and sciences

authors： Zainah H,Hassan M,Shiekh-Sroujieh L,Hassan S,Alangaden G,Ramesh M

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND AND AIM:There is no consensus regarding the benefit of eradicating Helicobacter pylori (H. pylori) infection in patients with functional dyspepsia (FD). We intended to compare the symptom response to H. pylori eradication in FD patients in presence or absence of microscopic duodenitis (MD). METHODS:Patients...

journal_title：Digestive diseases and sciences

authors： Mirbagheri SS,Mirbagheri SA,Nabavizadeh B,Entezari P,Ostovaneh MR,Hosseini SM,Rakhshani N,Safa H

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Transenteral (TE) administration of a bowel cleanser prior to colonoscopy avoids the discomfort associated with drinking a large volume of unpalatable cleanser. AIM:To explore patient comfort, preference for future colonoscopy, the efficacy and adverse events associated with TE bowel preparation. METHODS:B...

journal_title：Digestive diseases and sciences

authors： Jung SW,Jung DH,Shin YC,Moh IH,Yoo H,Jang SI,Shin SR,Kim JB,Park SH,Lee MS

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND AND AIMS:The Chronic Hepatitis Cohort Study (CHeCS) is a longitudinal observational study of risks and benefits of treatments and care in patients with chronic hepatitis B (HBV) and C (HCV) infection from four US health systems. We hypothesized that comparative effectiveness methods-including a centralized d...

journal_title：Digestive diseases and sciences

authors： Lu M,Rupp LB,Moorman AC,Li J,Zhang T,Lamerato LE,Holmberg SD,Spradling PR,Teshale EH,Vijayadeva V,Boscarino JA,Schmidt MA,Nerenz DR,Gordon SC

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Assessment and quantification of actual liver function is crucial in patients with chronic liver disease to monitor disease progression and predict individual prognosis. Mathematical models, such as model for end-stage liver disease, are used for risk stratification of patients with chronic liver disease but...

journal_title：Digestive diseases and sciences

authors： Malinowski M,Jara M,Lüttgert K,Orr J,Lock JF,Schott E,Stockmann M

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND AND AIMS:The optimal algorithm to identify Lynch syndrome (LS) among patients with colorectal cancer (CRC) is unclear. The definitive test for LS, germline testing, is too expensive to be applied in all cases. Initial screening with the revised Bethesda Guidelines (RBG) cannot be applied in a considerable nu...

journal_title：Digestive diseases and sciences

authors： Gould-Suarez M,El-Serag HB,Musher B,Franco LM,Chen GJ

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Antiviral therapy in addition to immunoprophylaxis at birth has been shown to further reduce perinatal transmission of hepatitis B virus (HBV) in highly viremic women. AIMS:The aim of this study was to describe the use of tenofovir disoproxil fumarate (TDF) prophylaxis to reduce maternal HBV DNA levels and ...

journal_title：Digestive diseases and sciences

authors： Tsai PJ,Chang A,Yamada S,Tsai N,Bartholomew ML

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND/AIM:Transarterial chemoembolization (TACE) is the recommended treatment for patients with Barcelona stage B hepatocellular carcinoma; however, community practice varies from these American Association for the Study of Liver Diseases guidelines. In this study, we sought to assess factors determining outcome a...

journal_title：Digestive diseases and sciences

authors： Barman PM,Sharma P,Krishnamurthy V,Willatt J,McCurdy H,Moseley RH,Su GL

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Diverticulosis, a prevalent condition at screening colonoscopy, has been associated with colorectal cancers that develop after a clearing colonoscopy, or interval cancers. AIMS:To quantify the overall risk of diverticulosis in the development of interval cancers and examine this association in relevant subg...

journal_title：Digestive diseases and sciences

authors： Cooper GS,Xu F,Schluchter MD,Koroukian SM,Barnholtz Sloan JS

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Peyer's patches (PPs), which are covered by specialized follicle-associated epithelium (FAE) including M cells, play a central role in immune induction in the gastrointestinal tract. This study is to investigate a new molecule to characterize PPs. METHODS:We generated a monoclonal antibody (mAb 10-15-3-3) t...

journal_title：Digestive diseases and sciences

authors： Tokuhara D,Nochi T,Matsumura A,Mejima M,Takahashi Y,Kurokawa S,Kiyono H,Yuki Y

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Mucosal addressin cell adhesion molecule-1 (MAdCAM-1), a member of the immunoglobulin superfamily, is essential for gut-specific homing of leukocytes; however, it has not been well characterized in rhesus macaques. AIMS:To obtain the complete nucleotide sequence of rhesus macaque MAdCAM-1 cDNA and determine...

journal_title：Digestive diseases and sciences

authors： Wang Y,Yao WR,Duan JZ,Xu W,Yang GB

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND AND AIM:To explore the CT signs which permit estimation of clinically severe portal hypertension (PH) [≥ 12 of hepatic vein pressure gradient (HVPG)]. METHODS:One-hundred and seven consecutive patients who underwent HVPG measurement in the PH group and 52 controls were included. The diameters of main portal...

journal_title：Digestive diseases and sciences

authors： Lee JY,Kim TY,Jeong WK,Kim Y,Kim J,Kim KW,Kim YH,Sohn JH

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Minimally invasive interventions for choledocholithiasis are preferable in elderly patients because they tend to have multiple underlying disorders or a decreased activity of daily living. Endoscopic sphincterotomy and endoscopic papillary balloon dilation have been recognized as first-line treatments for ch...

journal_title：Digestive diseases and sciences

authors： Tonozuka R,Itoi T,Sofuni A,Itokawa F,Kurihara T,Tsuchiya T,Ishii K,Tsuji S,Ikeuchi N,Umeda J,Tanaka R,Honjyo M,Mukai S,Fujita M,Moriyasu F

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND AND AIM:Simultaneous dilatation of the common bile duct and pancreatic duct, "double-duct sign" (DDS), is an ominous finding concerning for pancreaticobiliary malignancy. Little evidence exists to guide the initial evaluation and subsequent follow-up for patients with DDS in the absence of jaundice or focal ...

journal_title：Digestive diseases and sciences

authors： Cohen J,Sawhney MS,Pleskow DK,Chuttani R,Patel NJ,Sheridan J,Berzin TM

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:As several factors can contribute to low bone mineral density (BMD), we investigated the role of vitamin D in low BMD while controlling for other risk factors in inflammatory bowel diseases (IBD) patients. METHODS:We conducted a prospective cross-sectional study between 2008 and 2012 in adult IBD patients. ...

journal_title：Digestive diseases and sciences

authors： Abraham BP,Prasad P,Malaty HM

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Fulminant hepatic failure (FHF) is a devastating syndrome, which sometimes results in death or liver transplantation, in which inflammation would aggravate the development of fetuin-A which would act as an anti-inflammatory factor and may be an available approach to attenuate FHF. AIMS:The purpose of this s...

journal_title：Digestive diseases and sciences

authors： Zhang P,Shen H,Huang J,Wang H,Zhang B,Zhou R,Zhong B,Fan X

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Nonalcoholic fatty liver disease (NAFLD) is now recognized as a leading cause of liver dysfunction. Gastroesophageal reflux disease (GERD) is a common disorder causing symptoms that often impair patients' quality of life. In recent years, the prevalence of both these diseases has increased, partially overlap...

journal_title：Digestive diseases and sciences

authors： Catanzaro R,Calabrese F,Occhipinti S,Anzalone MG,Italia A,Milazzo M,Marotta F

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:No previous studies have compared cytology obtained under endoscopic transpapillary gallbladder drainage (ETGD) and EUS-guided fine needle aspiration (EUS-FNA) for thick-walled gallbladders. AIM:The present study investigated the diagnostic yield of bile cytology under ETGD and EUS-FNA for gallbladder tumor...

journal_title：Digestive diseases and sciences

authors： Ogura T,Kurisu Y,Masuda D,Imoto A,Onda S,Kamiyama R,Hayashi M,Mohamed M,Uchiyama K,Higuchi K

更新日期：2014-08-01 00:00:00